A thought experiment

What is the root cause of type 2 diabetes?

The medically correct answer may still stop too early. So we kept asking one deceptively simple question: But what causes that?

But what causes that?

Ask an AI, “What is the root cause of type 2 diabetes?” The answer will probably be sophisticated and medically sound.

It may identify insulin resistance, progressive pancreatic β-cell dysfunction, chronic excess calorie intake, ectopic fat accumulation and genetic susceptibility.

Those are causes—but are they root causes?

If chronic excess calorie intake is a major driver, why do so many people chronically consume more energy than their bodies can safely handle? The modern environment makes calorie-dense food inexpensive, convenient, abundant and constantly available, while everyday life requires less physical activity.

Why does the environment have those characteristics? Industrial food systems have become extraordinarily effective at producing, distributing and marketing inexpensive, convenient, highly rewarding foods. Companies compete for purchases, market share and growth. Successful products are copied, optimized, distributed more widely and promoted more aggressively.

Why does the system repeatedly reward those outcomes? Public corporations are expected to grow. Managers are rewarded for increasing sales, earnings and shareholder value. Companies that find effective ways to increase consumption gain an advantage over companies that do not.

No conspiracy is required. It is a selection process.

That leads to the central hypothesis behind this site: corporate incentive structures may be one of the most important upstream forces transforming normal human biological vulnerabilities into a population-scale type 2 diabetes epidemic.

But intellectual honesty requires us to challenge our own answer too.

What if corporate structures are not the root either?

Why are humans vulnerable to this environment in the first place?

Human beings evolved where calories were comparatively difficult to obtain. Strong preferences for energy-rich food could be advantageous when food was scarce. Technology changed that environment extraordinarily quickly: agriculture increased availability, industrialization made calories cheaper, food processing made them more convenient and rewarding, and machines reduced physical work.

Human biology adapted to scarcity is now operating in technological abundance.

Under that interpretation, corporations did not create the vulnerability. They discovered an enormously profitable opportunity within it. Corporate competition then acts as an accelerator—continually finding better ways to formulate, price, distribute and market products that humans are predisposed to consume.

Maybe there is no single root cause.

Type 2 diabetes may be better understood as an emergent result of interacting systems:

evolved human biology × technological abundance × corporate incentives × culture × public policy × the built environment

Change one variable and the outcome can change substantially. That brings us to an important counterexample.

The Japan problem.

Japan is wealthy, technologically advanced and highly industrialized. It has major corporations, processed food, advertising, convenience stores and sedentary occupations. Yet adult diabetes prevalence is substantially below that of the United States.

Culture may be one important answer. Food culture influences portion size, meal composition, snacking, sweetness, convenience, attitudes toward body weight and what consumers consider normal food. Urban design influences everyday movement. Government policy and regulation can constrain commercial behavior. Corporations must respond to those differences.

Corporate incentives create pressure, but culture and institutions can determine how that pressure is expressed.

When global corporations enter a society with a strong traditional food culture, who ultimately changes whom? Do corporations adapt to the culture? Does the culture gradually adapt to commercially optimized food? Or do both happen simultaneously?

If countries adopt the products, eating patterns and lifestyles pioneered in highly commercialized economies and their metabolic disease burden subsequently rises, those trajectories may tell us considerably more than a snapshot today. That is a question worth investigating rather than assuming the answer.

A better question.

Perhaps “What is the ultimate root cause?” is less useful than: “If we could change one upstream factor, which change would produce the largest reduction in type 2 diabetes?”

That is a question about leverage, not philosophical causation.

  • Human evolutionary biology is currently difficult to change at population scale.
  • Technology and food abundance are things most of us would not want to eliminate.
  • Changing an entire national culture is extraordinarily difficult.
  • Individual behavior requires changing the decisions of millions of people, continuously.

Corporate incentive structures are different. They sit upstream of product formulation, portion size, pricing, availability, distribution, advertising, food marketing, lobbying and resistance to regulation.

A narrower, more defensible hypothesis

Among realistically changeable upstream factors today, corporate incentive structures may be one of the highest-leverage intervention points in the type 2 diabetes epidemic because they simultaneously influence many of the environmental conditions that drive population exposure.

That is not the same as proving that corporations “cause diabetes.” Nor does it mean individuals have no agency, biology does not matter, or every corporation behaves identically. It asks where, in an enormously complicated causal system, one change could produce the greatest downstream effect.

The most important question may be the simplest.

Whenever we thought we had reached the answer, we asked: But what causes that?

Insulin resistanceWhat causes that?
Chronic excess energyWhat causes that?
The modern food environmentWhat causes that?
Commercial incentivesWhat causes those?
Human preferences, technology, economic structures, culture and institutionsAnd what causes those?

At some point, going further upstream stops making the explanation more useful. “Deeper” does not automatically mean “better.” The objective is not infinite causal regression. It is to identify the level—or combination of levels—that explains the most, survives serious counterarguments and gives us meaningful leverage over the outcome.

The corporate-structure hypothesis should therefore not be protected from criticism. It should be attacked. Japan should be investigated. Alternative explanations should be tested. Counterexamples should be actively sought. And if a better explanation emerges, the thesis should change.

The purpose of asking “What is the root cause?” should not be to defend the answer we already have. It should be to discover the answer we do not.